BALB/c mice are a widely used general-purpose model in biomedical research. They have a known genetic background and their H2d haplotype makes them a useful tool for studying immune responses, autoimmunity, and transplantation. Additionally, BALB/c mice have been used extensively in hybridoma development and monoclonal antibody production. They are also commonly used in infectious disease research, including studies on viral and bacterial infections, as well as cancer research.

C57BL/6 mice are a commonly used laboratory mouse strain that have a wide range of research applications, including as a general multipurpose model, for studying diet-induced obesity, developing transgenic/knockout models, and for safety and efficacy testing. They were first developed in 1921 and have undergone several generations of inbreeding to create a genetically stable and uniform strain. They have a specific MHC haplotype (H2bk) and are often bred using the Charles River International Genetic Standardization system.

CD-1® IGS mice were derived from a group of Swiss albino mice imported into the US in 1926. The Hauschka Ha/ICR stock was established in 1948 from these mice and was later designated as HaM/ICR at Roswell Park Memorial Institute. Charles River obtained the strain in 1959 and has since bred them using the International Genetic Standardization system. CD- 1® IGS mice are commonly used for general research purposes, safety and efficacy testing, aging studies, and various surgical models including pseudopregnancy.

CB6F1 mice are a hybrid strain resulting from the crossbreeding of female BALB/c mice and male C57BL/6 mice. They are also known as B6F1/Crl mice. This strain is widely used in transplantation research and monoclonal antibody production due to its unique genetic background. CB6F1 mice have a diverse range of applications in biomedical research, making them a valuable tool in various fields.

B6C3F1 mice are a hybrid strain obtained by crossing female C57BL/6 mice with male C3H mice, resulting in mice designated as B6C3F1/Crl. This strain is frequently used in various research fields, such as safety and efficacy testing, development of transgenic/knockout models, and transplantation research. Due to their well-characterized genetic background, these mice have proven to be valuable tools in biomedical research. Additionally, the strain is known for its sensitivity to certain environmental toxins, making it a useful model for studying chemical-induced carcinogenesis and other toxicological effects.

The NOD.CB17-Prkdcscid/NCrCrl mouse strain is a result of transferring the SCID mutation onto a non-obese diabetic (NOD) background. Homozygous animals for the SCID mutation have impaired T and B cell lymphocyte development, while the NOD background also leads to impaired natural killer (NK) cell function. The mouse strain was originally obtained from the National Institutes of Health (NIH) and later transferred to Charles River in 2003. The NOD.CB17-Prkdcscid/NCrCrl strain is commonly used in tumor biology and xenograft research.

CD (SD)® IGS rats are a multipurpose rat model derived from the outbred Sprague Dawley (SD) rats. The nomenclature for this model is Crl:SD. The model was originally developed by ARS/Sprague Dawley in 1979 and later transferred to SASCO. Charles River acquired the model in 1996. CD (SD)® IGS rats are commonly used in various research areas such as safety and efficacy testing, aging, nutrition, diet-induced obesity, and oncology. Due to their outbred nature, they exhibit high genetic variability and are widely used in a variety of research fields.