ANIMAL PRODUCED IN INDIA ( LOCAL BREEDING)

IMMUNODEFICIENT MODELS

Athymic Nude Foxn1 Mice (Crl:NU(NCr)-Foxn1nu)

This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010.

Fox Chase SCID Beige Mice (CB17.Cg-PrkdcscidLystbg-J/Crl)

To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. To Charles River in 1975 from CRUK. This particular colony was selected because of a low incidence of hydronephrosis. IGS refers to animals bred using the Charles River International Genetic Standardization (IGS) Program.

NOD

NOD SCID Mice

(NOD.CB17-Prkdcscid/NCrCrl )

This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010.

ncg

NCG Mice

(NOD-Prkdcem26Cd52Il2rgem26Cd22/NjuCrl)

To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. To Charles River in 1975 from CRUK. This particular colony was selected because of a low incidence of hydronephrosis. IGS refers to animals bred using the Charles River International Genetic Standardization (IGS) Program.

HYBRID MODELS

NOD

CB6F1/Crl Mice

This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010.

NOD

CD2F1/Crl Mice

To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. To Charles River in 1975 from CRUK. This particular colony was selected because of a low incidence of hydronephrosis. IGS refers to animals bred using the Charles River International Genetic Standardization (IGS) Program.

NOD

B6C3F1/Crl Mice

This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010.

NOD

B6D2F1/Crl Mice

To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. To Charles River in 1975 from CRUK. This particular colony was selected because of a low incidence of hydronephrosis. IGS refers to animals bred using the Charles River International Genetic Standardization (IGS) Program.

RAT MODELS

NOD

CD® (Sprague Dawley) IGS Rat

Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. To Charles River in 1950 from Sprague Dawley, Inc. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Rederived into an isolator foundation colony in 1997. IGS refers to animals bred using the Charles River International Genetic Standardization Program. Note: We also offer the CD® (SD) IGS SOPF Rat with a SOPF health profile (bred in France).

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WISTAR RATS CRL:WI

To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. To Charles River in 1975 from CRUK. This particular colony was selected because of a low incidence of hydronephrosis. IGS refers to animals bred using the Charles River International Genetic Standardization (IGS) Program.

MICE MODELS

NOD

C57BL/6N Mice (C57BL/6NCrl)

C57BL/6 mice are the most used inbred strain in research. Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results. Inbred mouse strains exhibit a high degree of uniformity in their inherited characteristics, or phenotypes, which include appearance, behavior, and response to experimental treatments.

F344_Rat_417x235_3

Athymic Nude Mice Crl:NU-FOX 1nu

This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010.

NOD

DBA/2 Mice (DBA/2NCrl )

C57BL/6 mice are the most used inbred strain in research. Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results. Inbred mouse strains exhibit a high degree of uniformity in their inherited characteristics, or phenotypes, which include appearance, behavior, and response to experimental treatments.

C3HMice

C3H Mice (C3H/HeNCrl)

This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010.

CD-1_Mouse_417x235_images

CD-1® ICR Mice (Crl:CD1(ICR))

The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research (ICR) in Philadelphia from “Swiss” mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To Charles River in 1959.

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Balb/c Mice (BALB/cAnNCrl)

H.J. Bagg developed the “Bagg albino” in 1913 from stock from an Ohio pet dealer. Inbred in 1923 by McDowell. To Snell in 1932 at F26, then to Andervont in 1935. To NIH in 1951 from Andervont at F72. To Charles River in 1974 from NIH.